Cite this article as:

Firsova S. S., Bucharskaya A. B., Maslyakova G. N., Zlobina O. V., Matveeva O. V., Bugaeva I. O., Khlebtsov N. G., Khlebtsov B. N., Bogatyrev V. A. The Changes of Morphological Indicators of Bone Marrow and Peripheral Blood at Long Exposure of Gold Nanoparticles. Izvestiya of Saratov University. New series. Series Physics, 2011, vol. 11, iss. 2, pp. 54-57.

Heading: 
Physics
UDC: 
576.6:576.33:615.017:616.079:615.2/.3.001.37:616091.8
Language: 
Russian

The Changes of Morphological Indicators of Bone Marrow and Peripheral Blood at Long Exposure of Gold Nanoparticles

Authors: 
Firsova S. S., Saratov State Medical University named after V. I. Razumovsky, Bolshaya Kazachia st., 112 Saratov, 410012 Russia, gmaslyakova@yandex.ru
Bucharskaya Alla Borisovna, Saratov State Medical University named after V. I. Razumovsky, Bolshaya Kazachia st., 112 Saratov, 410012 Russia, allaalla_72@mail.ru
Maslyakova Galina Nikiforovna, Saratov State Medical University named after V. I. Razumovsky, Bolshaya Kazachia st., 112 Saratov, 410012 Russia, gmaslyakova@yandex.ru
Zlobina O. V., Saratov State Medical University named after V. I. Razumovsky, Bolshaya Kazachia st., 112 Saratov, 410012 Russia, gmaslyakova@yandex.ru
Matveeva Olga Viktorovna, Research and Education Center of Basic Medicine and Nanotechnology, Saratov, Russia, ol-sar@bk.ru
Bugaeva I. O., Saratov State Medical University named after V. I. Razumovsky, Bolshaya Kazachia st., 112 Saratov, 410012 Russia, gmaslyakova@yandex.ru
Khlebtsov Nikolay Grigor’evich, Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences, 13, Prospekt Entuziastov, Saratov, 410049, Russia, khlebtsov@ibppm.ru
Khlebtsov Boris Nikolaevich, Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences, 13, Prospekt Entuziastov, Saratov, 410049, Russia, bkhl@ibppm.sgu.ru
Bogatyrev V. A., Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences, 13, Prospekt Entuziastov, Saratov, 410049, Russia, gmaslyakova@yandex.ru
Abstract

The exposure of gold nanoparticles with different size on the morphological indicators of red bone marrow and peripheral blood of white not purebred rats at long peroral introduction were studied in experiment. The mutagen influence of gold nanoparticles on polychromatophilous erythrocytes of bone marrow were estimated by micronuclear test. During research the reduction of quantity of leukocytes in peripheral blood and the erythrocyte volume reduction with increase of their hemoglobin saturation were revealed. The changes reflecting the mutagen activity of gold nanoparticles were not revealed at carrying out micronuclear test. The changes of morphological indicators of bone marrow testify about stimulation processes occurring in a marrow lymphocytic and myelocytic sprouts of hemopoiesis as a result of reduction of mature cells in peripheral blood.

Key words: 
gold nanoparticles, peripheral blood, red bone marrow
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