Presents clinical-immunological study of 26 patients with lichen planus (LP) (typical manifestations on the skin and mucous membranes). It was found that for the LP characterized by the appearance of the blood of an increased number of lymphocytes with active nuclear chromatin, which testifies to the intensive cellular immune response. Comparative evaluation of clinical effectiveness and impact on the immune response of the two methods of phototherapy (photochemotherapy (PUVA) and narrow-band UVB - therapy (UV-B 311нм)).