нефрон

Complex Waveforms and Synchronization in Functional Model of Vascular Nephron Tree

Authors: Scherbakov P. A., Astakhov O. V., Postnov D. E.

We suggest functional model that qualitatively describes oscillatory processes in renal autoregulation. Our model consists of ensemble of two-mode oscillators that are coupled by means of two different pathways. The above coupling pathways count both the geometry of ensemble (tree-like structure or local interaction) and the specific action of individual oscillator (energy distribution netrwork or diffusive coupling). We study the typical operating regimes of suggested model as well as transitions between them.

About Conditionality of Nonlinear Responce of Miogenic Response of Afferent Arteriola for Irregular Self-Sustained Oscillations of Nephron Proximal Pressure

Authors: Pavlova O. N., Postnov D. E.

By means of nonlinear dynamics and time series analysis we investigate the possible mechanisms for the onset of chaotic selfsustained dynamics in nephron tubular pressure that is observed experimentally. Our results suggests that the miogenic constriction mechanism of afferent arteriola plays the key role providing the nonlinear response on temporal variation of filtration rate.

TGF-Mode Elimination in Hemodynamics of Vascular Nephron Tree

Authors: Postnov D. D., Sosnovtseva O. V., Postnov D. E.

By means of numerical experiment, we studied the oscillating patterns, generated by the interaction of nephrons in the vascular tree and compared them with experimental data. Based on these results we calculated the blood flow in all branches, as well as its Fourier power spectra, to characterize its spectral composition. We reveal the mechanism responsible for the effective localization of hemodynamic interaction based on elimination of modulation rhythms of blood flow at each branching level.