Cite this article as:

Grigoriev . V., Manturov A. O. Kinetics of Diffusion-limited Elongation of DNA Fragments. Izvestiya of Saratov University. New series. Series Physics, 2014, vol. 14, iss. 2, pp. 57-59. DOI: https://doi.org/10.18500/1817-3020-2014-14-2-57-59

Heading: 
Physics
UDC: 
577.213.44; 577.31; 577.212.3
Language: 
Russian

Kinetics of Diffusion-limited Elongation of DNA Fragments

Authors: 
Grigoriev Anton Vladimirovich, Saratov State University, 410012, Russia, Saratov, Astrakhanskaya street, 83, strannik.anton@gmail.com
Manturov Alexey O., Saratov State University, 410012, Russia, Saratov, Astrakhanskaya street, 83, manturovao@gmail.com
Abstract

The numerical model of the elongation kinetics of the single-stranded DNA has been proposed and studied. The proposed model is based on the principles of the phenomenological modelling and implemented as diffusion cellular automata. The analytical and numerical estimates of the elongation reaction rate for different concentrations of nucleotides has been obtained. The possibility of nucleotide binding delays with reducing the concentration of one of the nucleotides in the solution is shown. 

Key words: 
deoxyribonucleic acid (DNA), elongation, diffusion, kinetics of the polymerization, nucleotides, DNA polymerase
DOI: 
https://doi.org/10.18500/1817-3020-2014-14-2-57-59
References

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2. Bai L., Shundrovsky A., Wang M. D. Sequence-dependent Kinetic Model for Transcription Elongation by RNA Polymerase // J. of Molecular Biology. 2004. Vol. 344. P. 335–349.

3. Марголус Н., Тоффоли Т. Машины клеточных автоматов / пер. с англ. М. : Мир, 1991. 280 с.

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