Cite this article as:

Navolokin N. A., Maslyakova G. N., Bucharskaya A. B., Suleymanova L. V., Kun S. M., Terentyuk G. S., Khlebtsov N. G., Khlebtsov B. N. Dynamics of Morphological and Biochemical Changes in Laboratory Animals with Transplanted Kidney Cancer after Intravenous Injection of Gold Nanoshells. Izvestiya of Saratov University. New series. Series Physics, 2012, vol. 12, iss. 2, pp. 38-43.

Heading: 
Physics
UDC: 
57.08:577.29:615: 576.6; 576.33: 616-091.8572:616.716.8(571.5)
Language: 
Russian

Dynamics of Morphological and Biochemical Changes in Laboratory Animals with Transplanted Kidney Cancer after Intravenous Injection of Gold Nanoshells

Authors: 
Navolokin Nikita Aleksandrovich, Saratov State Medical University named after V. I. Razumovsky, Bolshaya Kazachia st., 112 Saratov, 410012 Russia, navolokin1@rambler.ru
Maslyakova Galina Nikiforovna, Saratov State Medical University named after V. I. Razumovsky, Bolshaya Kazachia st., 112 Saratov, 410012 Russia, gmaslyakova@yandex.ru
Bucharskaya Alla Borisovna, Saratov State Medical University named after V. I. Razumovsky, Bolshaya Kazachia st., 112 Saratov, 410012 Russia, allaalla_72@mail.ru
Suleymanova Leila Vagidovna, Saratov State Medical University named after V. I. Razumovsky, Bolshaya Kazachia st., 112 Saratov, 410012 Russia, leylasuleymanova@mail.ru
Kun Syan Myao, Saratov State Medical University named after V. I. Razumovsky, Bolshaya Kazachia st., 112 Saratov, 410012 Russia, kobayakawamiyuki@sina.com
Terentyuk Georgy Sergeevich, Saratov State Medical University named after V. I. Razumovsky, Bolshaya Kazachia st., 112 Saratov, 410012 Russia, vetklinika@front.ru
Khlebtsov Nikolay Grigor’evich, Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences, 13, Prospekt Entuziastov, Saratov, 410049, Russia, khlebtsov@ibppm.ru
Khlebtsov Boris Nikolaevich, Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences, 13, Prospekt Entuziastov, Saratov, 410049, Russia, bkhl@ibppm.sgu.ru
Abstract

The effect of intravenously injected nanoshells on white outbred male rats with transplanted tumor of kidney cancer was studied. The blood biochemical parameters and morphological changes in the rat internal organs were examined during 24 h after nanoparticle injection. The most pronounced changes were observed 45 min – 2 h after nanoparticle injection and were reversible.

Key words: 
nanoparticles, gold nanoshells, toxicity, morphology, biochemistry, transplanted cancer, kidney cancer
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