Biophysics and medical physics

VIBRONIC SPECTRA AND STRUCTURE OF EXITED STATES OF POLYATOMIC MOLECULES

Authors: Ten G. N., Baranov V. I.
The methods of determination of molecular model parameters in exited electronic states are considered. Structural-dynamic models polyatomic molecules are developed using a semi-empirical method of hybridized atomic orbitals. It is shown that the electronic-vibrational spectra make it possible to identify the tautomeric forms in different phases states, taking into account the intermolecular interaction.

S0LIT0NS AND CLUSTERS IN ONE-DIMENSIONAL ENSEMBLES OF INTERACTING BROWNIAN PARTICLES

The survey of the studies results of 1D ensembles dynamics of interacting Browniam particles is presented. Properties of both particles and the Fermi-Pasta-Ulam, Toda, Lennard-Jones, Morse interaction potentials are described. The Langevin equations are exhibited and structures and thermodynamic characteristics which may be extracted from data of a numerical integration of the equations are described.

HETEROPHASE SEMICONDUCTORS UNDERACTION OF IRRADIATIONS

Authors: Stetsyura S. V., Rokakh A. G., Serdobintsev A. A.
The history and current state of our heteropfiase photoconducting CdS-PbS films investigations are observed. Films were prepared by the vacuum evaporation method from the materials with limited mu tual solubility. Reasons of increased degradation stability with respect to radiation (in particular y- and electronic irradiations) are found out. Degradation stability is explained by diversion of recombination flow from wide-gap phase to narrow-gap. Radiation stimulated defects also move to narrow-gap phase.

Leukocytes’ «Highlighting» Effect and its Application to Identify Blood Cells by Digital Microscopy Method

Authors: Doubrovski V. A., Torbin S. О.

Objective: To find a way of identifying and counting of leukocytes in a native blood sample.

Materials and equipments: Whole donor blood sample, digital microscop.

Methods and approaches: The development of a method of leukocytes’ identification and counting for native blood samples was carried out on the basis of digital microscopy method.

Albumin Conformational Changes During Glycation and Thermal Denaturation Processes Revealed by Fluorescence Spectroscopy and Small-angle X-ray Scattering

Authors: Rovnyagina N. R., Tikhonova T. N., Molodenskiy D. S., Shirshin E. А.

Background and Objectives: Objects of the research in this study are solutions of bovine serum albumin (BSA) and its aggregates. Structural changes of the protein molecules in solution with pH 3 and pH 7.4 are investigated during glycation and thermal denaturation processes, when the BSA molecules in solution undergo similar intermediate states. The main aim of the research is to compare structural changes of the BSA upon its glycation and thermal denaturation, revealed by combination of optical and X-ray techniques.

Investigation of the Interaction and Dynamics of Collagen and Collagenase Molecules in Solutions by Dynamic Light Scattering

Authors: Sergeeva I. А., Khitrina K. А., Krot A. R., Sukneva A. V., Petrova G. P.

Background and Objectives: Bacterial collagenase from Closrtidium histolyticum is widely used as a clinical tool in the nonsurgical treatment of Dupuytren’s disease in eye’s disorders treatment, for enzymatic debridement, for accelerated resorption of catgut sutures. Collagenase main feature is its ability to digest key protein of the animal extracellular matrix – collagen. Dynamic Light Scattering (DLS) technique allows for investigation of collagen and collagenase solutions in conditions close to physiological.

Monte Carlo Simulation of Laser Radiation Propagation in the Multilayers Model of Head and Brain Tissues in Health and in the Presence of Intracranial Hematoma

Authors: Belikov A. V., Skrypnik A. V., Antropova M. М.

Background and Objectives: Development of new optical methods of non-contact express diagnostics of intracranial hematoma remains an actual task. The development of optical model of the head in norm and in the presence of intracranial hematoma is the aim of the present study. Influence of the dimensions of the head tissues with and without hematoma on distribution of the backscattered laser radiation intensity is discussed.

Improved Data Processing Algorithm for Laser Ektacytometry of Red Blood Cells

Authors: Nikitin S. Y., Ustinov V. D., Tsybrov E. G., Priezzhev A. V.

Background and Objectives: Red blood cells deliver oxygen to organs and tissues. In case of tropical malaria, blood anemia, diabetes mellitus and many other diseases, the cells become corrupted. These pathologies lead in altering deformability of the cells, i.e ability to change their shape under external forces. Precise measurement of cell’s deformability gives important medical information which helps to cure and monitor the most wide spread diseases more effectively.

Optical Study of Blood Rheological Properties for Krushinsky – Molodkina Strain Rats with Diabetes Mellitus and Acute Disturbances of the Cerebral Circulation

Authors: Fadyukova O. Е., Lugovtsov A. Е., Priezzhev A. V., Koshelev V. B.

Background and Objectives: The aim of the study was to assess the hemorheological parameters for rats with experimental diabetes and acute disturbances of the cerebral circulation.

Optical Clearing of Cranial Bone by Multicomponent Immersion Solutions and Cerebral Venous Blood Flow Visualization

Authors: Genina E. A., Bashkatov A. N., Semyachkina-Glushkovskaya O. V., Tuchin V. V.

Background and Objectives: Optical clearing of bone tissue is of great practical interest, which opens up the possibility of the development of minimally invasive laser diagnostics and brain therapy. The aim of this work is the study of the optical clearing of cranial bone using multicomponent optical clearing agents, and the possibility of the measurement of cerebral blood flow.

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