Biophysics and medical physics

Applying Methods of Diffuse Light Scattering and Optical Trapping for Assessing Blood Rheological Parameters: Erythrocytes Aggregation in Diabetes Mellitus

Authors: Semenov A. N., Lugovtsov A. Е., Lee K., Fabrichnova A. А., Kovaleva Y. А., Priezzhev A. V.

Background and Objectives: Aggregation parameters of blood characterize red blood cells interaction processes which play a major role in the microcirculation regulation. It was shown that these parameters are significantly different in case of Diabetes Mellitus (DM) and therefore can be proposed as a novel parameter of the disease state and therapy efficiency.

Investigation of Delay Time in Interaction between the Regulatory Circuits in the Cardiovascular System of Healthy Humans Using Modeling of Phase Dynamics

Authors: Khorev V. S., Kiselev A. R., Shvartz V. A., Lapsheva E. E., Ponomarenko V. I., Prohorov M. D., Gridnev V. I., Karavaev A. S.

Background and Objectives: Low-frequency oscillations with a basic frequency of about 0.1 Hz are observed in the human heart rate and peripheral microcirculation. It is found out that these processes are self-oscillatory and interact between themselves. However, the details and characteristics of this interaction including the direction of coupling and delays in coupling functions are not well studied yet.

Influence of the Hydrogen Bond on the IR-spectrum and Structure of Molecular Complex of Diamond Nanoparticles and DNA Bases

Authors: Bokarev A. N., Plastun I. L., Agandeeva K. E.

Background and Objectives: Using molecular modeling by the density functional theory method we analyze a hydrogen bonds formation and their influence on IR-spectrum and structure of molecular complex which is formed as the interaction of complementary couple of DNA nucleobases adenine and timin and nanodiamonds surrounded with carboxylic groups. As an example of nanodiamonds adamantine has been used. Intermolecular forces and structure of hydrogen bonds are investigated.

Investigation of Mildronat ® Diffusion in Human Eye Sclera

Authors: Bashkatov A. N., Genina E. A., Kamenskikh T. G., Tuchin V. V.

Background and Objectives: Diseases of retina and optic nerve are the major causes of vision loss. The use of new drugs in the treatment of these diseases can reduce the decline of visual function due to the involvement of additional mechanisms of cell metabolism compensation. Thus, investigation of the drug diffusion in sclera is an important task at estimation of dose necessary for achievement of enough drug concentration in internal eye tissues.

Processing and Visualization of Large Data Arrays in Taxonomic and Evolutionary Studies of Living Nature1 (a review)

Authors: Shchyogolev, S. Y.

A review is given of recent advances in the taxonomic study of organisms and current views on biological evolution and the origin of life. The steady increase in bioinformation resources is noted, which reflects the results of studies of the Earth’s biodiversity with the use of deciphered structures of biomacromolecules (DNA, RNA, proteins, etc.). This necessitates accounting for the specific character of manipulations with large data arrays, which is currently termed the big data problem.

Study of Ethanol Impact on the Transepidermal Transport of Indocyanine Green with Backscattering Spectroscopy

Authors: Genina E. A., Bashkatov A. N., Tuchin V. V.

In the work, impact of aqueous 40%-ethanol solution on the transepidermal transport of photodynamic dye indocyanine green has been studied with backscattering spectroscopy. It has been first obtained the value of the dye diffusion coefficient through the stratum corneum ex vivo at the use of ethanol as a diffusion enhancer: (6.85±3.75)×10−7 cm2/s.