diffusion coefficient

Estimation of Glucose Diffusion Coefficient in Human Dura Mater

Authors: Bashkatov A. N., Genina E. A., Tuchin V. V.

Background and Objectives: Optical clearing of dura mater caused by hyperosmotic immersion liquids is important for the development of noninvasive methods of brain optical tomography and for the study of microcirculation and homeostasis of tissue fluids. It allows significantly increasing the spatial resolution and the probing depth of brain.

Investigation of Mildronat ® Diffusion in Human Eye Sclera

Authors: Bashkatov A. N., Genina E. A., Kamenskikh T. G., Tuchin V. V.

Background and Objectives: Diseases of retina and optic nerve are the major causes of vision loss. The use of new drugs in the treatment of these diseases can reduce the decline of visual function due to the involvement of additional mechanisms of cell metabolism compensation. Thus, investigation of the drug diffusion in sclera is an important task at estimation of dose necessary for achievement of enough drug concentration in internal eye tissues.

Study of Ethanol Impact on the Transepidermal Transport of Indocyanine Green with Backscattering Spectroscopy

Authors: Genina E. A., Bashkatov A. N., Tuchin V. V.

In the work, impact of aqueous 40%-ethanol solution on the transepidermal transport of photodynamic dye indocyanine green has been studied with backscattering spectroscopy. It has been first obtained the value of the dye diffusion coefficient through the stratum corneum ex vivo at the use of ethanol as a diffusion enhancer: (6.85±3.75)×10−7 cm2/s.