optical clearing

Optical Clearing as Method to Increase the Depth of Nanoparticles Detection in the Skin with OCT-Visualization

Authors: Zaytsev S. M., Bashkatov A. N., Tuchin V. V., Genina E. A.

Background and Objectives: Nanoparticles of titanium dioxide are now widely used both for the creation of sunscreen filters, and as carriers of drugs. One of the ways of transepidermal delivery of these nanoparticles to the dermis of the skin is their penetration into the hair follicles. However, optical control of the filling of follicles with nanoparticles is rather difficult due to strong light scattering in the skin.

On the Use of Optical Clearing in Strengthening the Sclera by Collagen Photocrosslinking

Authors: Shvachkina M. E., Pravdin A. B.

In the paper, the first evaluation results on the effect of optical clearing on the efficiency of the technique of eye sclera strengthening through the formation of riboflavin / ultraviolet collagen photocrosslinks are presented.

Optical Clearing of Human Eye Sclera by Aqueous 30%-Glucose Solution

Authors: Bashkatov A. N., Genina E. A., Kochubey V. I., Kamenskikh T. G., Tuchin V. V.

In this work, optical clearing of human eye sclera in vitro under action of aqueous 30% glucose solution was studied. It was shown that diffusion of glucose in tissue results in significant decrease of light scattering, which manifests itself in both decreasing reflectance and increasing transmittance of the samples. At that, absorption coefficient does not change. Measurements were performed with spectrophotometer CARY-2415 in the spectral range from 400 to 800 nm by a standard method.