photodynamic therapy

Prospects For Application of Upconversion Particles NaYF4:Er,Yb for Phototherapy

Authors: Sagaidachnaya E. A., Yanina I. Y., Kochubey V. I.

Background and Objectives: Functionalized upconversion particles allow for photodynamic and photothermal therapy of tumor with simultaneous temperature monitoring and visualization of the area of treatment. Upconversion particles can increase the depth of therapeutic effects due to the high penetration depth of the required excitation radiation. That is why they are a promising material for the combined phototherapy and simultaneous monitoring of biological tissue heating.

Photoactivated Disinfection in Treatment of Dental Pathology

Authors: Sitenkov D. E., Izgareva O. A., Kharitonova T. L., Gritsenko E. A.

The results of treatment and prevention in preschool children with inflammatory periodontal diseases. incorporating the lessons of oral hygiene, controlled cleaning of teeth and use of the device «Fotosan». After a preliminary analysis of the oral cavity (OHI-S, PMA), the children of the study were divided into two subgroups, one of which lasted for controlled cleaning of teeth, in the other - combined with the use of photoactivated disinfection. After application of photoactivated disinfection dynamics analysis allowed us to establish the PMA index decreased in preschool children by 92%.

Morphological Changes in Transplanted Sarcoma S45 at Photodynamic Therapy Using Nanocomposites Based on Gold Nanorods

Authors: Bucharskaya A. B., Genina E. A., Bashkatov A. N., Terentyuk G. S., Navolokin N. A., Maslyakova G. N., Khlebtsov N. G., Khlebtsov B. N., Tuchin V. V.

Photodynamic therapy (PDT) of cancer is an advanced application of gold nanostructures. The purpose of the research is to study the morphological changes in the transplanted sarcoma S45 at PDT using nanocomposites based on gold nanorods (GNRs). GNRs synthesized with the germ method and covered by a silicon coating, functionalized by hematoporphyrin, were intratumorally injected in rats with transplanted sarcoma S45. The tumor was irradiated by He-Ne laser with a wavelength of 632.8 nm.