gold nanorods

Morphological Changes in the Internal Organs and Implanted Liver Tumor after Intravenous Injection of Gold Nanorods in Rats with Diabetes and Transplanted Tumor

Authors: Bucharskaya A. B., Terentyuk G. S., Maslyakova G. N., Matveeva O. V., Navolokin N. A., Dicht N. I., Khlebtsov N. G., Khlebtsov B. N.

The effects of gold nanorods on the internal organs and the transplanted liver tumor were studied in rats with simulated alloxan diabetes and transplanted liver tumors after intravenous administration. Assessed morphofunctional changes and biodistribution of gold in the internal organs and transplanted liver tumor. The study found that a single intravenous injection of gold nanorods does not cause significant morphological changes in the internal organs and transplanted tumors in rats with alloxan diabetes and transplanted tumor.

Morphological Changes in Transplanted Sarcoma S45 at Photodynamic Therapy Using Nanocomposites Based on Gold Nanorods

Authors: Bucharskaya A. B., Genina E. A., Bashkatov A. N., Terentyuk G. S., Navolokin N. A., Maslyakova G. N., Khlebtsov N. G., Khlebtsov B. N., Tuchin V. V.

Photodynamic therapy (PDT) of cancer is an advanced application of gold nanostructures. The purpose of the research is to study the morphological changes in the transplanted sarcoma S45 at PDT using nanocomposites based on gold nanorods (GNRs). GNRs synthesized with the germ method and covered by a silicon coating, functionalized by hematoporphyrin, were intratumorally injected in rats with transplanted sarcoma S45. The tumor was irradiated by He-Ne laser with a wavelength of 632.8 nm.